DCLRE1B antibody

Catalog No. ABIN7113546

This anti-DCLRE1B antibody is a Rabbit Polyclonal antibody detecting DCLRE1B in WB and ELISA. Suitable for Human, Mouse and Rat.

Quick Overview for DCLRE1B antibody (ABIN7113546)

Target: DCLRE1B (DNA Cross-Link Repair 1B (DCLRE1B))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DCLRE1B antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-DCLRE1B Antibody

Purpose: DCLRE1B antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: DNA cross-link repair 1B(PSO2 homolog, S. cerevisiae)

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for DCLRE1B

Target: DCLRE1B (DNA Cross-Link Repair 1B (DCLRE1B))

Alternative Name: DCLRE1B

Background:

Synonyms: 5' exonuclease Apollo|Beta-lactamase DCLRE1B|DNA cross-link repair 1B protein|SNM1 homolog B (SNMIB, hSNM1B)|DCLRE1B|SNM1B

Background: 5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining(NHEJ)-mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop(T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres that are vulnerable to end-joining reactions and expose the telomere end in a manner that activates the DNA repair pathways. Together with TERF2, required to protect telomeres from replicative damage during replication by controlling the amount of DNA topoisomerase(TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Also involved in response to DNA damage: plays a role in response to DNA interstrand cross-links(ICLs) by facilitating double-strand break formation. In case of spindle stress, involved in prophase checkpoint.

Molecular Weight: 60 kDa

Gene ID: 64858

UniProt: Q9H816